Friday, 15 June 2018

Join us #Rome, Italy #Pancreas 2018 #https://pancreas.cmesociety.com/scientific-program

Pancreas 2018 @ Rome, Italy ; June 18-19, 2018

Finally we are near the conference date.

Hope to see you all in Rome, Italy!

Expecting the unexpected participants & excitements in our conference

Make your presence to make this event successful 

Saturday, 9 June 2018

Pancreas 2018 #Finalized Program #Experts gathering #Rome city #Join soon with us

Finally we are near to the conference. We are happy to release our conference scientific program

Hope the chance is still there for you to make to the conference, try your best and get the opportunity to meet global experts ! 

For more details have a look at: http://pancreas.cmesociety.com/

Regarding scientific program PS: https://pancreas.cmesociety.com/scientific-program

To participate PS: https://pancreas.cmesociety.com/registration

Catch us at: pancreas@gastroenterologysociety.com

Monday, 28 May 2018

Make sure that you will be present for Pancreas 2018 @Rome, Italy #June 18-19, 2018 #Oral presentation by Hildegard M. Schuller #Pancreatic Tumor- Category


Abstract


Abstract Content:


Pancreatic ductal adenocarcinoma (PDAC), is the leading histological type of pancreatic cancer with incidence rising and a very high mortality within one year of diagnosis. We have pioneered the concept that the highly coordinated hyperactivity of pancreatic cancer stem cell self-renewal, cell proliferation, angiogenesis, metastatic potential and drug resistance is regulated by neurotransmitter receptors that are the recipients of signals from the autonomic nervous system. We as well as others have thus shown that either stress or drug-induced hyperactivity of the sympathetic branch of the autonomic nervous system, resulting in systemic increases of the catecholamine neurotransmitters epinephrine and norepinephrine, significantly stimulated the growth of PDAC in mouse xenografts via hyperactive cAMP-dependent signaling downstream of Gs-coupled beta-adrenergic receptors. Treatment of the animals with g-aminobutyric acid (GABA) completely reversed this effect via inhibition of cAMP formation in response to binding of GABA to Gi-coupled GABAB receptors. The general beta-blocker propranolol had similar effects via inhibition of cAMP formation downstream of Gs-coupled beta-adrenergic receptors. Using a hamster model of pancreatitis-associated PDAC, we additionally showed that treatment of the animals with GABA effectively prevented the development of PDAC. Stress reduction via environmental enrichment also significantly reduced the development and progression of PDAC xenografts in mice. In each of these animal models, the observed inhibition of PDAC growth and progression was accompanied by decreases in cAMP-dependent signaling of  multiple proteins associated with cell proliferation, cell migration, stem cell self-renewal and angiogenesis. In vitro investigations with human PDAC cell lines confirmed the central role of cAMP hyperactivity downstream of Gs-coupled receptors as the driving force of PDAC growth suggested by the animal experiments. Collectively, these findings identify the opposing roles of PDAC stimulating Gs-coupled neurotransmitter receptors and PDAC inhibiting Gi-coupled neurotransmitter receptors as promising novel targets that can be successfully used for the prevention and therapy of PDAC by restoration of  cAMP homeostasis via psychological as well as pharmacological agents that are already widely used for the therapy of several non-neoplastic diseases.

Thursday, 17 May 2018

Hurry up #Make use of this opportunity to meet experts #Final Call #Do make your presence in Rome, Italy

                                        One final call from Pancreas 2018 !



We have recently updated our conference Scientific Program for the knowledge of other experts and delegates who are interested in attending the conference. If you are one among them do have a look at the link: https://pancreas.cmesociety.com/scientific-program

To know more about our conference please visit: https://pancreas.cmesociety.com/

For registration details: https://pancreas.cmesociety.com/registration

To make use of this discount do follow the below process:

URL: https://www.pulsusconference.com/payment

In this do select Conference as : Pancreas 2018, June 18-19, 2018 , Italy

Type of registration: You can select your package according to your convenience.